Association, Depression, Major Depressive Disorder (MDD), Metabolic Syndrome, Waist Circumference, Abdominal Obesity, Body Mass Index (BMI), High Density Lipoprotein (HDL), Ypoalphalipoproteinemia, Hypertriglyceridemia, Diabetes Mellitus (DM), Blood Glucose, Hyperinsulinemia, Insulin Resistance, Hypertension (HTN)


Purpose: To explore whether there is an association between metabolic syndrome (MetS) and depression, the nature of the relationship, and implications for practicing health care professionals. Data Sources: Peer reviewed articles obtained through electronic database search in: CINAHL, The Cochrane Library, MEDLINE, and PsychINFO between the years of 2006 and 2013. Results: MetS and depression have a bidirectional association; MetS leads to depression and vice-versa. More severe depression has a stronger association with MetS. Increased waist circumference (AKA: abdominal obesity, body mass index [BMI]), elevated triglycerides, and low HDL cholesterol are the MetS components most commonly/strongly associated depression. Though not thoroughly evaluated, gender, age, and race were not found to impact this association. Implications for Practice: As patients with MetS are at higher risk for developing depression, and vice-versa, practitioners should evaluate patients with either condition for the presence of the other. Presence/severity of depression should be assessed with a screening instrument. In the reviewed articles no suggested treatment is given; MetS components and depression should each be treated independently. Caution should be exercised with TCA antidepressants as they are associated with abdominal obesity.


The College of Nursing showcases some of our best evidence based scholarly papers from graduate students in the Family Nurse Practitioner Program. The papers address relevant clinical problems for advance practice nurses and are based on the best evidence available. Using a systematic approach students critically analyze and synthesize the research studies to determine the strength of the evidence regarding the clinical problem. Based on the findings, recommendations are made for clinical practice. The papers are published in professional journals and presented at professional meetings.

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Master's Project

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Graduate Student

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Nursing Commons