acetaminophen, antipyretic, analgesic, immunization, prophylactic, vaccine


Nurse Practitioners (NPs) are on the frontlines providing parental education regarding vaccines. While there are several reasons for vaccine hesitancy, the potential side-effects of vaccine administration, such as pain and/or elevated temperature, are often cited as a parental concern. According to research, prophylactic administration of an antipyretic/analgesic medication, such as acetaminophen, reduces vaccine side-effects when administered prior to or at the time of vaccination. Additionally, the evidence that prophylactic administration of antipyretic/analgesic medication decreases antibody response to vaccinations is insufficient at this time. Thus, NPs should reassure parents that an antipyretic/analgesic medication can be administered prior to or at the time of vaccination to prevent or reduce side-effects, which may then reduce vaccine hesitancy among parents.


The College of Nursing showcases some of our best evidence based scholarly papers from graduate students in the Family Nurse Practitioner Program. The papers address relevant clinical problems for advance practice nurses and are based on the best evidence available. Using a systematic approach students critically analyze and synthesize the research studies to determine the strength of the evidence regarding the clinical problem. Based on the findings, recommendations are made for clinical practice. The papers are published in professional journals and presented at professional meetings.

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University Standing at Time of Publication

Assistant Professor

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Nursing Commons