ARID1A Knockout: a Catalyst for Osteosarcoma Progression

Authors

Alma Taggart, Brigham Young UniversityFollow
Peyton Worley, Brigham Young University
Heinen Louis, Brigham Young University
Emilee Nielson, Brigham Young University
Jared Barrott, Brigham Young University - ProvoFollow

Files

Keywords

cancer, mouse model

Abstract

Osteosarcoma (OS) is a rare form of bone cancer, with high mortality rates in children and young adults. Current OS research has been limited by a lack of mouse models that accurately represent the metastatic and chemoresistant nature of this cancer. Furthermore, by focusing on patient-derived xenograft models it limits the applications of novel immunotherapies because these mouse models lack a competent immune system. By knocking out Arid1a, we generated a mouse model that more accurately reflects the aggressive nature of the tumor with 100% penetrance of tumorigenesis and 41% penetrance of metastasis, while maintaining a competent immune system. This new mouse model allows for insights to better understand the tumor microenvironment (TME), and testing novel therapies.

BYU ScholarsArchive Citation

Taggart, Alma; Worley, Peyton; Louis, Heinen; Nielson, Emilee; and Barrott, Jared, "ARID1A Knockout: a Catalyst for Osteosarcoma Progression" (2025). Library/Life Sciences Undergraduate Poster Competition 2025. 72.
https://scholarsarchive.byu.edu/library_studentposters_2025/72

Document Type

Article

Publication Date

2025

Language

English

College

Life Sciences

Department

Cell Biology and Physiology

University Standing at Time of Publication

Junior

Copyright Use Information

https://lib.byu.edu/about/copyright/