Comparative Whole Genome Sequencing of Cryopreserved and FFPE Cancer Tissue

Authors

DeLaney Anderson, Brigham Young University - ProvoFollow
Ken Dixon, Specicare
Ryan Miller, Brigham Young University
Sangmoon Lee, Inocras
Jeffrey Okojie, Brigham Young University
Jared Barrott, Brigham Young University - ProvoFollow

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Keywords

Whole genome sequencing, cancer, genetics, comparative study

Abstract

Whole genome sequencing (WGS) determines the DNA sequence of an organism’s entire genome & plays a key role in cancer precision medicine

• Currently, the main preservation method of cancer tissue for WGS is formalin-fixed, paraffin-embedded (FFPE) tissue; cryopreserved (CP) tissue is not routinely used in clinical settings
• Previous studies have determined CP tissue yields higher quality & quantity of DNA
• This study aimed to compare the outcomes of WGS in CP & FFPE samples.

BYU ScholarsArchive Citation

Anderson, DeLaney; Dixon, Ken; Miller, Ryan; Lee, Sangmoon; Okojie, Jeffrey; and Barrott, Jared, "Comparative Whole Genome Sequencing of Cryopreserved and FFPE Cancer Tissue" (2025). Library/Life Sciences Undergraduate Poster Competition 2025. 68.
https://scholarsarchive.byu.edu/library_studentposters_2025/68

Document Type

Article

Publication Date

2025

Language

English

College

Life Sciences

Department

Cell Biology and Physiology

University Standing at Time of Publication

Senior

Copyright Use Information

https://lib.byu.edu/about/copyright/