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VOR Generalization in Mice

Abstract

The Vestibulo-Ocular Reflex (VOR) is a critical neural mechanism allowing the eye to stabilize vision during head movements by generating compensatory eye movements. The VOR can be adapted to make larger or smaller eye movements for the same amount of head movement by associating head movement with rotation of a visual field at a specific frequency The change in Serial = Sum of Sines Serial ≠ Sum of Sines Training frequencies change but no generalization occurs eye movement at one frequency of head rotation also induces smaller magnitude changes in eye movement at closely-related frequencies, a process termed generalization. It is not clear whether serial training at different rotation frequencies would produce the same generalization effects as combined training with multiple frequencies simultaneously. We hypothesize that generalization will be more effective for frequencies close to the training frequency most recently experienced, and less effective for training frequencies that were experienced more distantly, when presented in series. In contrast, we hypothesize that generalization will be equally effective across frequencies when training stimuli are presented simultaneously.

Document Type

Article

Publication Date

2025

Language

English

College

Life Sciences

University Standing at Time of Publication

Senior

Frequency-Specific Training of VOR Generalization in Mice

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