GCSF Involvement in Ethanol Dopamine Adaptations

Authors

Zachary Valentine, Brigham Young University - ProvoFollow
Chase Seiter, Brigham Young University
Rachel Campbell, Brigham Young University - Provo
Camryn Holt, Brigham Young University - Provo
Jordan T. Yorgason, Brigham Young University - ProvoFollow

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Keywords

Dopamine, Alcohol, Nucleus Accumbens, VTA, Addiction

Abstract

Objective: Investigate the role of Granulocyte-colony stimulating factor (GCSF) in ethanol-induced dopamine adaptations using fast-scan cyclic voltammetry.

Hypothesis: Prolonged alcohol exposure will weaken GCSF release, resulting in diminished effects on dopamine terminals.

Dopamine (DA) release in the nucleus accumbens (NAc) from the ventral tegmental area (VTA) plays a crucial role in learning stimuli associated with reward

Granulocyte-colony stimulating factor (GCSF) is a known neuromodulator for for DA release

Ethanol has been demonstrated to increase the firing rate of dopamine neurons in the (VTA)

The effects of ethanol on GCSF neuromodulation remains unknown

BYU ScholarsArchive Citation

Valentine, Zachary; Seiter, Chase; Campbell, Rachel; Holt, Camryn; and Yorgason, Jordan T., "GCSF Involvement in Ethanol Dopamine Adaptations" (2025). Library/Life Sciences Undergraduate Poster Competition 2025. 40.
https://scholarsarchive.byu.edu/library_studentposters_2025/40

Document Type

Article

Publication Date

2025

Language

English

College

Life Sciences

Department

Neuroscience

University Standing at Time of Publication

Senior

Copyright Use Information

https://lib.byu.edu/about/copyright/