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Keywords
Alcohol, addiction, bile acids, GLP-1, TGR5, nucleus accumbens, mesolimbic, Kupffer cell, voltammetry, patch clamp, liver
Abstract
Ethanol (EtOH) increases dopamine (DA) release, leading to addictive behaviors.
Ex vivo, EtOH only alters DA release at supraphysiological levels.
The liver metabolizes EtOH, and metabolites can escape into systemic circulation and cross the blood-brain barrier.
We hypothesize that these metabolites may induce changes in the mesolimbic circuitry and thus contribute to the reinforcing effects of EtOH.
We examined the effects of bile acids (BAs) and other EtOH metabolites on accumbal DA release and CIN firing.
We also investigated downstream effects of EtOH metabolism, such as macrophage migration and TGR5-mediated release of glucagon- like peptide-1 (GLP-1).
BYU ScholarsArchive Citation
Holt, Camryn; Roque, Isabella; Sharma, Shimran; Galbraith, Chris; and Yorgason, Jordan T., "Investigating the role of the liver-brain axis in addiction" (2025). Library/Life Sciences Undergraduate Poster Competition 2025. 32.
https://scholarsarchive.byu.edu/library_studentposters_2025/32
Document Type
Article
Publication Date
2025
Language
English
College
Life Sciences
Department
Neuroscience
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