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Keywords

gold nanorods antibody drug conjugate

Abstract

Antibody-drug conjugates (ADC) are burgeoning class of anti-cancer therapies. They rely on the specificity of antibodies to selectively deliver a cytotoxic payload to cancer cells expressing unique antigens. To minimize the toxicity of these ADCs, we designed a multipronged application with two separate components that by themselves are harmless, but when combined result in thermal toxicity to the tumor cells. Gold nanoparticles as the payload was one component and a near IR laser was the other. Gold nanoparticles are innocuous and exhibit localized surface plasmon resonance (LSPR). The LSPR of gold nanoparticles allows them to absorb photons at certain wavelengths, causing excitation and the release of heat. This feature allows gold nanoparticles to be used as a therapeutic tool. In this project the gold nanorods were conjugated to an anti-Oncostatin M Receptor (OSMR) antibody to target OSMR-expressing cancer cells. Thermotoxicity is induced in the cells where the conjugate resides by near IR laser activation of gold nanoparticles.

Document Type

Book

Publication Date

2025

Language

English

College

Life Sciences

Department

Cell Biology and Physiology

University Standing at Time of Publication

Sophomore

Synthesis of gold nanorods as payloads for antibody drug conjugates for synovial sarcoma

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Life Sciences Commons

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