P39 Effects on Accumbal DA in Young vs. Old Mice
Dopamine, Aging, AMPK pathway, ZMP
Dopamine (DA) release decreases in the nucleus accumbens (NAc)with age, which has been linked to neurodegenerative conditions. ZMP acts as an endogenous activator of AMPK which is correlated to increased DA signalling. P39, exogenous ZMP, also activates the AMPK pathway necessary for DA release. The objective of this study was to examine if the presence of P39 restored these depleted levels of DA in aged mice.
BYU ScholarsArchive Citation
Lee, Serin; Mcfarlane, Jared; Brundage, Hannah; and Yorgason, Jordan, "P39 Effects on Accumbal DA in Young vs. Old Mice" (2022). Library/Life Sciences Undergraduate Poster Competition 2022. 5.
Cell Biology and Physiology
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