Effects of Ivermectin as an Allosteric Modulator of nAChRs on Dopamine Release
neuroscience, reward, brain, drugs
- Dopamine (DA) terminals are regulated by acetylcholine activity on nicotinic receptors (nAChRs).
- Nicotine reduces DA release from low frequency stimulation, but enhances release at higher frequencies.
- Ivermectin (IVM) is a known positive allosteric modulator of nAChRs and has been shown to enhance L-dopa effects in Parkinson’s disease animal models.
- Present study examines the effects of allosteric nAChR activity on DA terminal function via IVM.
BYU ScholarsArchive Citation
Barlow, Joshua; Hafen, Caylor; Robinson, J. Kayden; Steimle, Emma; Wadsworth, Hillary; Foote, Sarah E.; Bishop, Samantha; Graul, Benjamin E.; and Yorgason, Jordan, "Effects of Ivermectin as an Allosteric Modulator of nAChRs on Dopamine Release" (2022). Library/Life Sciences Undergraduate Poster Competition 2022. 46.
Cell Biology and Physiology
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