Quantifying the Effects of Potential Small Molecule CHIKV Therapeutics in Human Macrophage Cells
Therapeutics, viruses, chikungunya, transcriptomics, data analysis
Chikungunya virus (CHIKV) is a mosquito-borne pathogen that causes ~1.1 million human infections annually. Human infections can develop arthralgia and myalgia, which results in debilitating pain for weeks, months, and even years after acute infection. No therapeutic treatments or vaccines currently exist for many alphaviruses, including CHIKV. Targeting the phagocytosis of CHIKV by macrophages after mosquito transmission plays an important role in early productive viral infection in humans, and could reduce viral replication and/or symptoms. For more than a year, our team has used computational analyses to predict pharmaceutical treatments for debilitating viral infections. Specifically, our research navigates the complexities of identifying safe therapeutic treatments for people infected with CHIKV.
BYU ScholarsArchive Citation
Gray, Madison; Ahlborn, Gene; and Pickett, Brett E., "Quantifying the Effects of Potential Small Molecule CHIKV Therapeutics in Human Macrophage Cells" (2022). Library/Life Sciences Undergraduate Poster Competition 2022. 25.
Microbiology and Molecular Biology
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