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CD5, Metabolism, CD4+ T cells
T cells serve a key role in the immunological response in the adaptive system. Different receptors present on the T cell have certain roles and are able to either inhibit or stimulate signaling which consequently regulates the function and metabolism of the cell. CD5 is an inhibitory co receptor expressed on the surface of T cells known to regulate thymocyte selection and TCR signaling . Our goal is to better understand the effects of CD5 regulation in metabolism. Using metabolic flux assays, we found that CD5KO naïve T cells have increased glycolysis and mitochondrial respiration in comparison to wild type naïve T cells. Using GC MS, significant differences in amino acid levels in both the T cells and the serum of CD5WT and CD5KO mice were identified. Understanding the metabolism of CD5 regulation could elevate our knowledge of immunotherapies and adaptive immune responses in treating diseases like cancer.
BYU ScholarsArchive Citation
Bennett, Joshua; Whitley, Kiara; Freitas, Claudia PhD; Haynie, Christopher; Moreno, Carlos; and Weber, Scott, "The Role of CD5 in CD4+ T cell Metabolism" (2022). Library/Life Sciences Undergraduate Poster Competition 2022. 18.
Microbiology and Molecular Biology
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