The T cell co-receptor CD5 alters mouse behavior and gut microbiome composition
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CD5, Gut Microbiome, Behavioral Study
Behavior is affected by psychological and biological factors. The central nervous system, immune system, and gut microbiota work together to affect our mental health and cognitive behaviors. Immune cell development is influenced by the gut microbiota. T cells help regulate immune responses to foreign microbes. T cell activation is enhanced or inhibited by co-receptor proteins on the cell membrane, which can dramatically affect T cell function and immune responses. CD5, a T cell co-receptor, modulates T cell activation by inhibiting T cells from being able to be activated by self-proteins in order to prevent potential autoimmune effects. Our project studies the CD5 protein co-receptor and its effects on the microbiota, immune response, and central nervous system by testing mice that have the protein (CD5WT), mice that don't have the protein (CD5KO) and their progeny. We hypothesize that CD5 alters the gut microbiota which, in turn, alters the cognitive behavior of these mice. To investigate this hypothesis, we will conduct a series of behavioral tests based on both genotype and microbiome composition. This project will bring greater understanding to the intersection of the immune system, gut microbiota, and the central nervous system.
BYU ScholarsArchive Citation
Reaveley, Kyle; Whitley, Kiara V.; Freitas, Claudia T.; Cox, Tyler; Magoffin, Wyatt; von Wallwitz, Isabella; Mahler, Kimble; Haynie, Christopher; Tall, Alexa; Teasdale, Joshua; and Weber, K. Scott, "The T cell co-receptor CD5 alters mouse behavior and gut microbiome composition" (2021). Library/Life Sciences Undergraduate Poster Competition 2021. 3.
Microbiology and Molecular Biology
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