Exploring the Mechanism of “Forgetting” with Electrophysiology
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synaptic plasticity, depotentiation
- An estimated six million Americans suffer from neurological disorders such as Alzheimer's and Dementia (Alzheimer's Association, 2021). Studying the brain in the context of synaptic plasticity, or how the brain changes and adapts, can shed new light on the effects of aging and these forgetting disorders.
- Long-term potentiation is the strengthening of synapses and is correlated with learning and memory. Depotentiation is the weakening of synapses and is correlated with “forgetting." Understanding these two opposing processes may be helpful in learning more about the inner workings of the brain.
- There are several factors that may affect depotentiation, including the age of the brain, the types of neuronal membrane receptors involved, and the duration of LTP prior to depotentiation. Using electrophysiology, we are investigating the role these factors play in "forgetting.”
BYU ScholarsArchive Citation
Holdaway, Matt; Bever, Nick; Valentine, Noah; and Edwards, Jeff, "Exploring the Mechanism of “Forgetting” with Electrophysiology" (2021). Library/Life Sciences Undergraduate Poster Competition 2021. 21.
Physiology and Developmental Biology
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