Variation of DNA Methylation in Pediatric Cancer Patients
Download Poster (228 KB)
methylation, pediatric cancer, bioinformatics, oncogenes, tumor suppressor genes
The development of pediatric cancer is a complex process. Because fewer genetic abnormalities have been identified in pediatric cancer patients than other cancer patients, it is thought that dysregulation of the epigenome plays a role in pediatric cancer development1. DNA methylation is a mechanism of epigenetic modification in which methyl groups are attached to DNA molecules, making it more difficult for DNA to be transcribed and translated into protein. Methylation can have an impact on gene expression when methylation levels significantly increase or decrease2. We hypothesized that methylation levels of genes are consistent in normal patients and variant in pediatric cancer patients. We chose to focus on patients with Wilms tumor, rhabdoid tumor, clear cell sarcoma of the kidney, osteosarcoma, and neuroblastoma.
BYU ScholarsArchive Citation
Parker, Alyssa C.; Quinteros, Badi; and Piccolo, Stephen R., "Variation of DNA Methylation in Pediatric Cancer Patients" (2021). Library/Life Sciences Undergraduate Poster Competition 2021. 2.
Copyright Use Information