When Mutations Don’t Matter: A Context-dependent Phenotype of a Cancer Gene
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cancer, proteomics, copy number amplification, EGFR
Cancer occurs when mutations lead to dysfunctional biological pathways. While many studies have identified cancer mutations, we do not fully understand the functional effects of mutations. In many cancers, there are often extra copies of the epidermal growth factor receptor (EGFR) gene (copy number amplification). EGFR is a tyrosine kinase which activates multiple pathways resulting in cell growth and metastasis. Understanding the effects of EGFR mutations will help improve current EGFR therapies by determining if therapies could be used in multiple cancer types.
BYU ScholarsArchive Citation
Olsen, Lindsey; Henderson, Brittany; Boekweg, Hannah; and Payne, Sam, "When Mutations Don’t Matter: A Context-dependent Phenotype of a Cancer Gene" (2021). Library/Life Sciences Undergraduate Poster Competition 2021. 1.
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