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Keywords

Anticancer, peptide, DFT, quantum, QM/MM, computational

Abstract

Yaku’amide A was isolated in late 2010 from the deep-sea sponge Ceratopsion sp. and exhibits potent inhibitory activity against 39 human cancer cell lines via a potentially novel mode of action. However, the total synthesis requires many steps and produces low yields. In this study, we determined two simpler YA analogues that may retain its anticancer properties and can be synthesized in larger quantities. The analogues replace dehydroisoleucine with either dehydroethylnorvaline or dehydrovaline.

Document Type

Poster

Publication Date

2018-03-29

Language

English

College

Physical and Mathematical Sciences

Department

Chemistry and Biochemistry

University Standing at Time of Publication

Senior

Progress Toward Synthetically Simplified Natural Anticancer Peptide

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