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multiple sclerosis, uric acid, primary progressive, relapsing remitting
Multiple sclerosis (MS) is a neurodegenerative disease caused by demyelination in the central nervous system. In previous studies, serum uric acid (UA) levels have been implied as a useful biomarker in understanding MS disease progression and development. The majority of previous studies have found MS patients have a lower UA level than healthy controls, however some studies have found higher UA levels with MS patients. Previous studies have compared UA levels between subtypes of MS, but have not produced conclusive data. To better understand the correlation between UA levels and MS patients, we compared UA levels between our set of MS patients from the Vanderbilt BioVU database, which includes the electronic health records of ~7,000 MS patients.
In 499 MS patients and 276 healthy controls with UA results, Both gender and age were found to be contributing factors to UA levels (p = 5.979e-10 and p=4.448e-5). With both age and gender as covariates, we found no significant different UA levels associated with MS patients (regression, p=0.0858). UA levels were compared to MS subtype with no significant association (p = 0.628)
Our study failed to support previous evidence of low UA levels associated with MS patients. Gender and age were identified as contributing factors to UA level. There was no significant difference found between UA levels of different subtypes of MS.
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BYU ScholarsArchive Citation
Gosch, Alexander A.; Davis, Mary F.; and Denny, Joshua C., "Uric Acid Levels in Relation to Progression of Multiple Sclerosis" (2016). Library/Life Sciences Undergraduate Poster Competition 2017. 1.
Microbiology and Molecular Biology
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