Journal of Undergraduate Research


RAGE, SAGE, therapeutic modalities for COPD


Life Sciences


Physiology and Developmental Biology


Funding available through this MEG award has provided an opportunity for me to meet many academic objectives I’ve determined to be important at BYU. We have been successful in conducting pilot studies that reveal possible roles for SAGEs in ameliorating mechanisms of lung inflammation induced by and cigarette smoke (CS). Despite improvement in personal air quality during the past few decades, the rationale for studying mechanisms leading to adverse health effects remains important. This MEG award specifically provided opportunities for students to conduct meaningful research that led to the observation that alveolar epithelial cells and bronchiolar epithelial cells experience elevated inflammatory signaling following exposure and that SAGEs may be effective in attenuating inflammation via RAGE abrogation.

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