Nrf2 in Protecting Against Valproic Acid-¬‐Induced Oxidative Injury During Cellular Differentiation

Authors

Alyssa Palmer, Brigham Young University
Jason Hansen, Brigham Young University

Keywords

Nrf2, valproic acid, oxidative injury, cellular defferentiation

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

The causes of the majority of birth defects remain largely unknown today. However, many chemicals known to cause defects are also known inducers of oxidative stress, resulting in faulty cellular function. This suggests an important link between oxidative stress and normal and abnormal embryonic development [1]. Oxidative stress is a phenomenon caused by an imbalance in the production of reactive molecules derived from oxygen called reactive oxygen species (ROS). Although basal levels of ROS are necessary in order for normal cell function to occur, an overabundance of ROS interact with molecules that they shouldn’t, disrupting vital cellular pathways. This is termed oxidative stress.

Recommended Citation

Palmer, Alyssa and Hansen, Jason (2019) "Nrf2 in Protecting Against Valproic Acid-¬‐Induced Oxidative Injury During Cellular Differentiation," Journal of Undergraduate Research: Vol. 2019: Iss. 2019, Article 126.
Available at: https://scholarsarchive.byu.edu/jur/vol2019/iss2019/126