The Role of Nrf2 In Prevention of Oxidative Stress Caused by Valproic Acid

Authors

Madison Wilson, Brigham Young University
Jason M. Hansen, Brigham Young University

Keywords

Nrf2, oxidative stress, valproic acid

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Valproic acid (VPA) is a common drug used to treat epileptic seizures as well as bipolar disease. Over the past decade, the use of these drugs has increased dramatically as they are now being prescribed as antipsychotics, mood stabilizers, and are currently being tested as chemotherapeutics and for managing human immunodeficiency virus infection. VPA also leads to birth defects when pregnant mothers take this drug. The most prevalent of these birth defects is spina bifida, a defect resulting from improper neuronal development, leading to deformation of the spinal cord. However, because of the effectiveness of the drug for some expecting mothers, VPA therapies are unavoidable.

Recommended Citation

Wilson, Madison and Hansen, Jason M. (2019) "The Role of Nrf2 In Prevention of Oxidative Stress Caused by Valproic Acid," Journal of Undergraduate Research: Vol. 2019: Iss. 2019, Article 125.
Available at: https://scholarsarchive.byu.edu/jur/vol2019/iss2019/125