Journal of Undergraduate Research


iron dysregulation, oxidative stress, prevention, skeletal muscle cells


Life Sciences


Nutrition, Dietetics, and Food Science


Recent studies indicate a correlation between iron dysregulation and insulin sensitivity, suggesting that iron dysregulation may play a role in the development of type 2 diabetes mellitus [1]. However, the connection between iron regulation and insulin sensitivity is not fully understood. Iron is normally tightly regulated, and most iron within cells is bound to prevent aberrant production of free radicals. Non-bound iron is highly reactive via Fenton Reaction chemistry to produce hydroxyl radicals, contributing to oxidative stress and possibly to the development of insulin resistance. Not only does mismanagement of iron contribute to oxidative stress, but evidence suggests that oxidative stress may play a role in disrupting iron regulation [2]. Furthermore, while many studies characterizing this iron dysregulation have been done in liver, less work has been done to understand the role that iron dysregulation may play in other tissues important to glucose sensitivity such as skeletal muscle. We therefore chose a cell model of C2C12 mouse skeletal muscle cells to characterize oxidative stress-induced iron dysregulation in skeletal muscle.

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