The Effects of Hyperlipidemia on β-Cells

Authors

Andrew Barlow, Brigham Young University
Trevor Lloyd, Brigham Young University
Mason Poffenbarger, Brigham Young University
Austin Ricks, Brigham Young University
Dr. Jeffery Tessem, Brigham Young University

Keywords

hyperlipidemia, β-Cells, diabetes

College

Life Sciences

Department

Nutrition, Dietetics, and Food Science

Abstract

Diabetes’ prevalence is increasing at an alarming rate. Normally, insulin-secreting β-cells in the pancreas regulate proper glucose absorption and storage. Type 1 and Type 2 diabetes are characterized by decreased functional β-cell mass and insulin production (1). Diabetes also results in increased circulating glucose and fatty acid levels, which damage and destroy β-cells over time (2). Our study sheds further light on the palmitate and oleate-induced effects of gradually worsening hyperlipidemia and the mechanisms behind those effects; ultimately, promoting investigation into methods by which existing β-cells could be protected from harmful hyperlipidemia.

Recommended Citation

Barlow, Andrew; Lloyd, Trevor; Poffenbarger, Mason; Ricks, Austin; and Tessem, Dr. Jeffery (2019) "The Effects of Hyperlipidemia on β-Cells," Journal of Undergraduate Research: Vol. 2019: Iss. 2019, Article 123.
Available at: https://scholarsarchive.byu.edu/jur/vol2019/iss2019/123