NF κB as a Mediator in Iron Regulation

Authors

Erik D. Marchant, Brigham Young University
Chad Hancock, Brigham Young University

Keywords

NF κB, iron regulation, cancer, doxorubicin, DOX

College

Life Sciences

Department

Nutrition, Dietetics, and Food Science

Abstract

Doxorubicin (DOX) is a commonly used chemotherapy drug. Although it is very effective in treating many different types of cancer, it has also been shown to induce oxidative stress in multiple tissues, partially due to severe iron-dysregulation. The effects of DOX have mostly been studied in heart tissue, because DOX has been shown to increase the risk of cardiomyopathy and other heart diseases. Besides causing damage to the heart, DOX has also been shown to contribute to muscle wasting. For this purpose, we decided to investigate how DOX causes iron-dysregulation in C2C12 myotubes, which are immortalized cells from mouse skeletal muscle.

Recommended Citation

Marchant, Erik D. and Hancock, Chad (2019) "NF κB as a Mediator in Iron Regulation," Journal of Undergraduate Research: Vol. 2019: Iss. 2019, Article 122.
Available at: https://scholarsarchive.byu.edu/jur/vol2019/iss2019/122