Journal of Undergraduate Research


TK1, chemosensitivity, metastatic, breast tumors


Life Sciences


Microbiology and Molecular Biology


Breast cancer is the most common form of cancer in women, accounting for 23% of total cancer cases and 14% of cancer deaths. Breast carcinoma is not a simple disease. It is comprised of many different biological forms with distinct phenotypes and prognoses. Hormone receptor expression, such as ER, PR, and HER2, along with more universal clinical manifestations like pathological stage, grade, and lymph node invasion are often used for patient prognosis. The heterogeneous nature of breast tumors makes prognosis and response to therapies difficult to determine, and further research is needed to classify breast tumors and their response to traditional therapies.

This study documents the potential of Thymidine Kinase 1 (TK1) to be utilized as a marker of malignant potential and sensitivity to chemotherapies in breast cancers. TK1 is an enzyme active during the S phase of the cell cycle that contributes to DNA synthesis, and is thought to contribute to a high proliferative potential in cancerous cells.

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