Chemokine Receptor CCBP2-V41A and its Role in Inflammation and Alzheimer’s Disease

Authors

Allen Weinert, Brigham Young University
Scott Weber, Brigham Young University

Keywords

chemokine receptor, CCBP2-V41A, inflammation, alzheimer's disease

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

The leading cause of dementia in elderly patients is Alzheimer’s disease (AD), a degenerating and fatal neurodegenerative condition. AD is a proteopathic disease caused by extensive accumulation of amyloid beta plaques and neurofibrillary tangles. A recent genomewide association study analyzing 59 AD-associated cerebrospinal fluid (CSF) samples statistically associated chemokine receptor mutant CCBP2-V41A with increased CSF protein levels of the proinflammatory chemokine CCL2. CCBP2 is a known binding partner of CCL2. We hypothesized that CCBP2-V41A receptor alters CSF levels of CCL2 and that raised CCL2 levels alters immune cell function, resulting in amyloid beta deposition in the brain (Figure 1).

Recommended Citation

Weinert, Allen and Weber, Scott (2019) "Chemokine Receptor CCBP2-V41A and its Role in Inflammation and Alzheimer’s Disease," Journal of Undergraduate Research: Vol. 2019: Iss. 2019, Article 113.
Available at: https://scholarsarchive.byu.edu/jur/vol2019/iss2019/113