Journal of Undergraduate Research


inflammation in the eye, mechanical stress, osteoarthritis, metabolic syndrome


Life Sciences


Physiology and Developmental Biology


A correlation between Osteoarthritis (OA), affecting over 27 million people in the US [1], and metabolic syndrome (MS), affecting over 340 million people worldwide [2], becomes strikingly important as the search for an effective treatment for OA continues. Increasing evidence has shown that OA is linked to systemic inflammation and MS. With MS comes other substantial comorbidities, including diabetic retinopathy (DR). Ocular inflammation promoted through mechanically induced OA would provide evidence that mechanical stress can be a factor leading to systemic inflammation. Such results would have profound impacts upon the way we view OA as a metabolic disorder, leading to novel treatments for OA and perhaps other diseases.

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