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Journal of Undergraduate Research

Keywords

MafB, β-Cell growth and proliferation, glucose stimulated insulin

College

Life Sciences

Department

Nutrition, Dietetics, and Food Science

Abstract

Project Purpose: Our goal is to determine if MafB is necessary for β Cell proliferation and glucose stimulated insulin secretion (GSIS). Project Importance: Approximately 29.1 million people are affected by type 1 or type 2 diabetes in the United States, according to 2014 National Diabetes Statistic Report. In addition, these 29.1 spent or lost 245 billion dollars combined. A cure for diabetes would result in not only a better life style but would also save billions of dollars. Project Profile Body: Both forms of diabetes are ultimately caused by decreased functional β-cell mass. β-cell transplantation is a possible treatment for people with diabetes, however there is a lack of β-cell donors. A potential solution is to expand β-cells ex vivo to be used for transplantation. Thus, defining the pathways that allow β-cells to replicate, while still being able to secrete insulin in response to elevated blood glucose, is essential. The Tessem lab is focused on defining the molecular mechanisms that allow β-cells to replicate while maintaining or improving β- cell survival and function.

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