Journal of Undergraduate Research


TK1, cytoplasm, cell membrane, cancer patients


Life Sciences


Microbiology and Molecular Biology


Thymidine Kinase 1 is an enzyme involved in the synthesis of thymidine triphosphate, an essential DNA building block needed for cell replication. Previous research has shown an upregulated level of TK1 in the serum levels of cancer patients as well as on the cancer cell surface. Due to its’ abnormal presence on the surface of various cancer cells, it is being researched as a potential biomarker for future immunotherapies. In order to be a more reliable biomarker, we need a more in depth understanding of the mechanism of how this protein travels through the cell cytoplasm and eventually attaches on the external side of the cell membrane.