Journal of Undergraduate Research


multiple NGF treatments, regeneration in peripheral nerves, Nerve Growth Factor


Ira A. Fulton College of Engineering and Technology


Chemical Engineering


The purpose of this project is to develop an effective treatment for damaged nerves. A team led by Dr. Cook has been working in this area for several years. Their project used a combination of biochemical treatments on rats with damaged sciatic nerves to improve the rate and quality of regeneration. The team is comparing the recovery of the nerves through a treatment receiving a combination of Lysophosphatidylcholine (LPC) and Nerve Growth Factor (NGF) with a treatment receiving only NGF and with a control that receives no treatment. LPC has been shown to upregulate the trkA receptor for NGF, thus increasing the effectiveness of NGF treatments. The results of this study showed no significant difference in the rate of regeneration over 6 weeks.