Multiple NGF Treatments Enhance Regeneration in Peripheral Nerves

Authors

Keaton Karlinsey, Brigham Young University
Alonzo Cook, Brigham Young University

Keywords

multiple NGF treatments, regeneration in peripheral nerves, Nerve Growth Factor

College

Ira A. Fulton College of Engineering and Technology

Department

Chemical Engineering

Abstract

The purpose of this project is to develop an effective treatment for damaged nerves. A team led by Dr. Cook has been working in this area for several years. Their project used a combination of biochemical treatments on rats with damaged sciatic nerves to improve the rate and quality of regeneration. The team is comparing the recovery of the nerves through a treatment receiving a combination of Lysophosphatidylcholine (LPC) and Nerve Growth Factor (NGF) with a treatment receiving only NGF and with a control that receives no treatment. LPC has been shown to upregulate the trkA receptor for NGF, thus increasing the effectiveness of NGF treatments. The results of this study showed no significant difference in the rate of regeneration over 6 weeks.

Recommended Citation

Karlinsey, Keaton and Cook, Alonzo (2017) "Multiple NGF Treatments Enhance Regeneration in Peripheral Nerves," Journal of Undergraduate Research: Vol. 2017: Iss. 1, Article 6.
Available at: https://scholarsarchive.byu.edu/jur/vol2017/iss1/6