Journal of Undergraduate Research
Keywords
synthesis of yaku'amide A, cancer cell, nonapeptide
College
Life Sciences
Department
Chemistry and Biochemistry
Abstract
Yaku’amide A (YA) has potent toxicity against cancer cells (IC50 = 14 ng/ml against P388 murine leukemia cells). Ueoka et al.1 first reported the isolation of YA from a marine sponge in the East China Sea. They used spectroscopy and chemical degradations to analyze its structure. YA contains unique dehydroamino acids (See Figure 1). In the growth inhibition study, YA showed unique activity against 39 cancer cell lines, indicating a novel mode of action. The unusual structure of YA and its prominent biological activity has attracted research groups from around the world to address its synthesis.
Recommended Citation
Luo, Shi and Castle, Steven
(2017)
"The total synthesis of yaku’mide A,"
Journal of Undergraduate Research: Vol. 2017:
Iss.
1, Article 290.
Available at:
https://scholarsarchive.byu.edu/jur/vol2017/iss1/290