Journal of Undergraduate Research
Keywords
BBSome, bardet-biedl syndrome, kidney disease, mental retardation
College
Life Sciences
Department
Chemistry and Biochemistry
Abstract
Bardet-Biedl Syndrome (BBS) occurs when an eight-protein complex called the BBSome is improperly assembled and can no longer function. The BBSome is responsible for trafficking membrane proteins to cilia, a projection from the cell surface packed with receptors that allow the cell to sense its surroundings. Loss of BBSome function causes malformation of cilia and leads to vision loss, obesity, kidney disease and mental retardation.
Recommended Citation
Ludlam, Grant and Willardson, Barry
(2017)
"Determining the Structure of the BBBSome,"
Journal of Undergraduate Research: Vol. 2017:
Iss.
1, Article 289.
Available at:
https://scholarsarchive.byu.edu/jur/vol2017/iss1/289