Journal of Undergraduate Research
Keywords
diverse tissue, organ systems, secondhand cigarette smoke
College
Life Sciences
Department
Physiology and Developmental Biology
Abstract
The receptor for advanced glycation end-products (RAGE) is a pattern recognition receptor expressed in many cell types, including smooth muscle cells, fibroblasts, macrophages, and epithelial cells (1). RAGE is capable of binding a variety of endogenous ligands, included advanced glycation end-products (AGEs), S100/calgranulins, amyloid-beta peptides, and HMGB1 (2). RAGE signaling has been identified as a primary mediator in a variety of feed-forward inflammatory pathways and, as such, has been implicated in a variety of chronic conditions of inflammation such as chronic obstructive pulmonary disease (COPD), pancreatitis, and diabetic cardiomyopathy (3-5).
Recommended Citation
Gassman, Jason and Reynolds, Dr. Paul R.
(2017)
"Diverse Tissue and Organ Systems Differs Following Exposure to Secondhand Cigarette Smoke,"
Journal of Undergraduate Research: Vol. 2017:
Iss.
1, Article 236.
Available at:
https://scholarsarchive.byu.edu/jur/vol2017/iss1/236