Development of a Directed Forward Genetic Screen Using CRISPR Libraries

Authors

Robert C. Russell, Brigham Young University
Johnathon Hill, Brigham Young University

Keywords

CRISPR libraries, genetic screen using, congenital heart defects

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Thousands of genes control the development of our bodies. These genes must be activated at the proper place and time in order for development to proceed correctly. The technique that we are developing will improve our ability to identify such genes, thus providing insights to the mechanisms underlying development processes. One in 33 live births in the United States is impacted by a birth defect. Of these, congenital heart defects (CHDs) are the most common, affecting nearly 1% of births in the United States.1 For this reason, we are developing a technique that will identify key contributors in heart development.

Recommended Citation

Russell, Robert C. and Hill, Johnathon (2017) "Development of a Directed Forward Genetic Screen Using CRISPR Libraries," Journal of Undergraduate Research: Vol. 2017: Iss. 1, Article 229.
Available at: https://scholarsarchive.byu.edu/jur/vol2017/iss1/229