A Microfluidic Approach to Measuring Endothelial Cell Migration

Authors

Keywords

microfluidic approach, measuring endothelial cell migration, pathological angiogenesis

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

Pathological angiogenesis or new vessel growth plays a key role in a number of diseases including tumor growth and several eye diseases that can lead to blindness. While antiangiogenic therapies have been developed for many of these pathologies, there remains a pressing need for more effective anti-angiogenic therapy with fewer side-effects. Capillary morphogenesis gene 2 (CMG2) has been shown to play an important role in angiogenesis and is a potential target for future anti-angiogenic therapies. To better understand the physiological role of CMG2 and to accurately compare how well different CMG2 antagonists inhibit endothelial cell migration (the putative mechanism for how CMG2 functions as an antiangiogenic target), we have developed a more robust endothelial cell migration assay which is typically plagued by low precision and reproducibility.

Recommended Citation

(2017) "A Microfluidic Approach to Measuring Endothelial Cell Migration," Journal of Undergraduate Research: Vol. 2017: Iss. 1, Article 227.
Available at: https://scholarsarchive.byu.edu/jur/vol2017/iss1/227