Identifying the Upstream Target of Resveratrol in Breast Cancer Cells

Authors

Jeffrey Mecham, Brigham Young University
Jason Kenealey, Brigham Young University

Keywords

upstream target, resveratrol, breast cancer cells, DNA repair

College

Life Sciences

Department

Nutrition, Dietetics, and Food Science

Abstract

One commonly disrupted pathway in many different cancer cells lines revolves around the tumor suppressor protein _p53. Approximately half of human cancers exhibit direct, inactivating mutations of _p53, while the majority of the remainder either elevate inhibitors, reduce activators, or deactivate downstream targets of _p53¹. The central role of _p53 in preventing tumorigenesis stems from its ability to induce controlled cell death of unhealthy cells, along with DNA repair and cell cycle arrest.

Recommended Citation

Mecham, Jeffrey and Kenealey, Jason (2017) "Identifying the Upstream Target of Resveratrol in Breast Cancer Cells," Journal of Undergraduate Research: Vol. 2017: Iss. 1, Article 226.
Available at: https://scholarsarchive.byu.edu/jur/vol2017/iss1/226