Journal of Undergraduate Research
Keywords
HDAC1, B-cell proliferation, decreased p15 expression
College
Life Sciences
Department
Nutrition, Dietetics, and Food Science
Abstract
The body maintains normoglycemia through pancreatic β-cells which sense elevation in circulating glucose levels and secrete insulin to maintain the correct blood glucose concentration. A decrease in functional pancreatic β-cell mass leads to Type 1 or Type 2 diabetes. Each form has different initial causes, but both forms ultimately result in decreased functional β-cell mass. Functional β-cell mass is defined as the rate of glucose stimulated insulin secretion multiplied by the total β-cell mass. The total β-cell mass is a function of cellular proliferation and death rates. β-cells have a very low proliferation rate, therefore determining the mechanisms that induce β-cell replication for pancreatic islet transplantation, or increasing the endogenous β-cell population could be used to cure diabetes.
Recommended Citation
Kener, Kyle and Tessem, Jeffery
(2017)
"Is HDAC1 mediated β-cell proliferation dependent on decreased p15 expression?,"
Journal of Undergraduate Research: Vol. 2017:
Iss.
1, Article 224.
Available at:
https://scholarsarchive.byu.edu/jur/vol2017/iss1/224