Effect of High Expression of IRF5 on B Cell Activation After Antigen Stimulation

Authors

KalareLyn Eberting, Brigham Young University
Brian Poole, Brigham Young University

Keywords

highexpression of IRF5, B cell activation, antigen stimulation

College

Life Sciences

Department

Microbiology and Molecular Biology

Abstract

While autoimmune diseases are very prevalent in the United States, little is understood about the cause of autoimmunity, making it difficult to take preventative measures and develop treatments. Previous studies have determined that a common genetic risk factor across many autoimmune diseases leads to B cell overexpression of the transcription factor IRF5 (1,2,4). Researchers have also discovered that high IRF5 levels are strongly associated with autoantibody production, suggesting that IRF5 may play a role in actually causing autoimmunity. At this point, however, it is unclear how IRF5 promotes the production of autoantibodies.

Recommended Citation

Eberting, KalareLyn and Poole, Brian (2017) "Effect of High Expression of IRF5 on B Cell Activation After Antigen Stimulation," Journal of Undergraduate Research: Vol. 2017: Iss. 1, Article 204.
Available at: https://scholarsarchive.byu.edu/jur/vol2017/iss1/204