Alzheimer’s Risk Genes and Pathways of Expression

Authors

Samantha Jensen, Brigham Young University
John Kauwe, Brigham Young University

Keywords

Alzheimer's disease, risk genes, pathways of expression

College

Life Sciences

Department

Biology

Abstract

Although Alzheimer’s disease (AD) has been the subject of research for nearly 100 years, these decades of research have not led to a unified understanding of the mechanisms behind the disease pathology1 ,2. Recent improvements in whole genome sequencing have made it possible for researchers to find a large number of mutations implicated in AD. Due to a high frequency of false positives and confounding factors, many mutations being investigated for therapies may not even have a causative effect on Alzheimer’s expression. Without concrete knowledge of the interactions of the proteins and genes implicated in the disease, drug development has been unsuccessful.

Recommended Citation

Jensen, Samantha and Kauwe, John (2017) "Alzheimer’s Risk Genes and Pathways of Expression," Journal of Undergraduate Research: Vol. 2017: Iss. 1, Article 178.
Available at: https://scholarsarchive.byu.edu/jur/vol2017/iss1/178