Journal of Undergraduate Research


pVAAST, Alzheimer's disease, sequencing project pedigree data


Life Sciences




Alzheimer’s disease is a progressive brain disorder affecting more than 10 percent of Americans over the age of 65 (1). This disease destroys memory and thinking skills and is a leading cause of dementia. Although research in recent years has provided substantial information related to risk factors associated with Alzheimer’s disease, a great deal of information still remains unknown. PVAAST is a software tool that can analyze genome sequence data of Alzheimer’s patients in a creative way by also analyzing the patients’ pedigree information. With the combined information from family members, it is more feasible to identify genetic mutations related to Alzheimer’s disease. The objective of this analysis was to learn valuable information that will aid in identifying risk factors for Alzheimer’s disease and creating effective intervention.

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