•  
  •  
 

Journal of Undergraduate Research

Keywords

pluripotent stem cell, iPSC, kidney phenotype, conditioned media of RCTEs

College

Ira A. Fulton College of Engineering and Technology

Department

Chemical Engineering

Abstract

According to the latest U.S. Renal Data System Annual Data Report, more than 660,000 Americans are currently being treated for kidney failure, also called end stage renal disease (ESRD). The current treatment options, dialysis and kidney transplants, work well in some instances but have disadvantages, such as the inability to perform hormone regulation and potential organ rejection respectively.

The overall aim of our work is to create bioengineered kidneys that will provide alternative solutions to the current treatment methods without any of the drawbacks. New breakthroughs in the biomedical world support the theory that organs can be grown from cultured induced pluripotent cells (iPSCs). This is what we plan to accomplish as a research team. Our end goal is to be able to grow these kidneys from human patient cells such that they can have functioning kidneys for transplant without the risk of organ rejection. Specifically for this project, we aimed to successfully differentiate pluripotent stem cells into kidney cells that could be used to develop a functioning kidney.

Download

Share

COinS