Journal of Undergraduate Research


ROS production, meth exposure, methamphetamine, dopamine


Family, Home, and Social Sciences




Methamphetamine is an extremely addictive drug that acts on the pleasure center of the brain. It causes an increase in the release of dopamine (DA) into the synaptic cleft. This rapid release of DA causes the “rush” felt by drug users. It also causes severe malfunctions in the brain such as anxiety, mood disorders, increased violence, reduced motor skills, impaired verbal learning, and psychosis. Among other things, the cause for these harmful effects could be related to Reactive Oxygen Species (ROS) and their resulting oxidative damage. Oxidative damage has been suggested to constitute early signaling events in programmed cell death, contributing to the idea that it may be the primary source of damage done to the neural tissue from Meth.

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