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Journal of Undergraduate Research

Keywords

epigenetic cost matrix, comparable to genetic, DNA fragments

College

Physical and Mathematical Sciences

Department

Computer Science

Abstract

Epigenetics is of vital importance, comparable to genetics, in predicting the outcome of illnesses. Bisulfite sequencing (BS) provides short DNA fragments that must be mapped in order to discover epigenetic markers. The purpose of this project is to find an optimal cost matrix to map sequences from BS DNA to a reference genome to determine patterns of methylation. A more efficient BS cost matrix will contribute to the ongoing effort to understand the epigenome and analyze data collected.

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