Testing the Effect of Antioxidants on the pathogenesis of Alzheimer’s disease through the RAGE/NF-kB Inflammatory Pathway

Authors

Harrison Snyder, Brigham Young University
Jonathan Wisco, Brigham Young University

Keywords

antioxidants, pathogenesis of Alzheimer's disease, RAGE/NF-kB, inflammatory pathway

College

Life Sciences

Department

Physiology and Developmental Biology

Abstract

The Receptor for Advanced Glycation Endproducts (RAGE) is known to have a role in inflammatory processes. When produced in excess it induces oxidative stress by activating a number of ligand enzymes, resulting in the generation of excessive cytosolic reactive oxidant species. This oxidative stress then stimulates Nuclear Factor Kappa-B (NF-kB), which regulates immune response and inflammation. When RAGE is incorrectly regulated, inflammation occurs in otherwise healthy tissue, a process implicated in neurodegenerative disorders like Alzheimer’s disease. RAGE is found throughout the body and is seen in greater concentration in inflamed tissues; it has also been found in the brain tissue of Alzheimer’s disease patients, leading to a potential link between the molecule and the disease.

Recommended Citation

Snyder, Harrison and Wisco, Jonathan (2016) "Testing the Effect of Antioxidants on the pathogenesis of Alzheimer’s disease through the RAGE/NF-kB Inflammatory Pathway," Journal of Undergraduate Research: Vol. 2016: Iss. 1, Article 177.
Available at: https://scholarsarchive.byu.edu/jur/vol2016/iss1/177