Journal of Undergraduate Research


Alzheimer's disease, p.V236E variant, ApoE gene, SNP


Life Sciences


Physiology and Developmental Biology


I was interested in trying to validate the findings of the publication by Medway et al. concerning the SNP rs199768005 using data from the Cache Country data set. Unfortunately, of the 4703 people from our data set, only 10 were carriers. Using R statistical analysis, I found that the p-value for this SNP with an association to protect for Alzheimer’s Disease (AD) was not significant. It was similarly not significant in its association with Any AD. I also ran other models to include for factors such as education or age in conjunction with this SNP and its association with AD or Any AD. The SNP was not significant in any of the models, regardless of other factors included, in its association with Alzheimer’s Disease.