Journal of Undergraduate Research


HDAC1, B-cell glucose stimulated insulin, apoptosis resistance


Life Sciences


Nutrition, Dietetics, and Food Science


Type 1 and type 2 diabetes affects more than 9% of the American population and the incidences of diabetes continue to increase at a startling rate. Both Type 1 and Type 2 diabetes impede β- cell function (insulin secretion) by destroying β-cell mass. Increasing proliferation and function of β-cells could potentially be used as a cure for diabetes. Research has shown that the homeobox β-cell transcription factor Nkx6.1 induces β-cell proliferation. We have found that Nkx6.1 upregulates expression of HDAC1 and this project will allow us to further define the specific role of HDAC1 in increasing β-cell proliferation. We hypothesize that HDAC1 is essential in the β-cell proliferation pathway and could be used to increase insulin secretion and protect against cellular apoptosis.

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