The role of HDAC1 in increasing β-cell glucose stimulated insulin secretion and apoptosis resistance

Authors

Carrie Draney, Brigham Young University
Jeffery Tessem, Brigham Young University

Keywords

HDAC1, B-cell glucose stimulated insulin, apoptosis resistance

College

Life Sciences

Department

Nutrition, Dietetics, and Food Science

Abstract

Type 1 and type 2 diabetes affects more than 9% of the American population and the incidences of diabetes continue to increase at a startling rate. Both Type 1 and Type 2 diabetes impede β- cell function (insulin secretion) by destroying β-cell mass. Increasing proliferation and function of β-cells could potentially be used as a cure for diabetes. Research has shown that the homeobox β-cell transcription factor Nkx6.1 induces β-cell proliferation. We have found that Nkx6.1 upregulates expression of HDAC1 and this project will allow us to further define the specific role of HDAC1 in increasing β-cell proliferation. We hypothesize that HDAC1 is essential in the β-cell proliferation pathway and could be used to increase insulin secretion and protect against cellular apoptosis.

Recommended Citation

Draney, Carrie and Tessem, Jeffery (2016) "The role of HDAC1 in increasing β-cell glucose stimulated insulin secretion and apoptosis resistance," Journal of Undergraduate Research: Vol. 2016: Iss. 1, Article 171.
Available at: https://scholarsarchive.byu.edu/jur/vol2016/iss1/171