Journal of Undergraduate Research
Keywords
CDK5R1, β-cell survival, apoptosis, diabetes
College
Life Sciences
Department
Nutrition, Dietetics, and Food Science
Abstract
Type 1 and Type 2 diabetes are classified as a decrease in functional ß-cell mass, which results in impaired blood glucose regulation. Functional ß-cell mass is defined as the glucose stimulated insulin secretion rate multiplied by the total cellular mass which is determined by the proliferation and cell death rates. Though ß-cell mass proliferation rates generally decrease by adolescence, obesity and pregnancy have been shown to be times of significant ß-cell proliferation (1). This implies that the inherent molecular pathways necessary for ß-cell proliferation are present, but highly regulated. Discovering the molecular pathway of ß-cell proliferation could lead to diabetes treatment options including increasing the endogenous ß-cell population, or producing sufficient ß-cells ex vivo for islet transplantation.
Recommended Citation
Hobson, Amanda and Tessem, Jeffrey
(2016)
"The role of CDK5R1 in β-¬cell survival from apoptosis,"
Journal of Undergraduate Research: Vol. 2016:
Iss.
1, Article 168.
Available at:
https://scholarsarchive.byu.edu/jur/vol2016/iss1/168