Journal of Undergraduate Research


PAS kinase, gut microbiome, metabolism, diabetes onset, mice


Life Sciences


Microbiology and Molecular Biology


Diabetes and obesity are among the most prevalent health concerns in the modern world. However, prevention of their onset and control of their symptoms are still largely limited by our understanding of how these diseases arise. Recent research has indicated that the composition of the gut microbiome is one of the important factors in development of these diseases (5). However, current thinking is not definitive on the relative importance of genetic factors, diet and the gut microbiome, among other factors (5,6). PAS Kinase provided a model through which we could compare the relative affects of genetics, gut microbiome and diet in the development of diabetes and obesity. This project was designed to provide the comparative research that is needed to better understand how the different factors that contribute to diabetes and obesity interact and influence one another.

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